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. 2004 Apr 19;2004(2):CD004109. doi: 10.1002/14651858.CD004109.pub2

Comparison 15. High vs Moderate ICS Dose (Duration).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 FEV1 (% predicted) 4   Mean Difference (IV, Fixed, 95% CI) Subtotals only
1.1 <= 12 weeks 1 12 Mean Difference (IV, Fixed, 95% CI) 11.40 [0.85, 21.95]
1.2 > 12 weeks 3 118 Mean Difference (IV, Fixed, 95% CI) 3.83 [‐1.37, 9.04]
2 Morning PEF (L/min) 2   Mean Difference (IV, Fixed, 95% CI) Subtotals only
2.1 < =12 weeks 1 12 Mean Difference (IV, Fixed, 95% CI) ‐75.0 [‐228.70, 78.70]
2.2 >12 weeks 1 51 Mean Difference (IV, Fixed, 95% CI) 10.0 [‐14.39, 34.39]
3 Morning PEF (L/min) change from baseline 5   Mean Difference (IV, Fixed, 95% CI) Subtotals only
3.1 < =12 weeks 3 320 Mean Difference (IV, Fixed, 95% CI) 2.93 [‐10.07, 15.93]
3.2 >12 weeks 2 797 Mean Difference (IV, Fixed, 95% CI) 7.00 [‐1.80, 15.79]
4 Diary Card Symptom Score (day) change baseline 2   Mean Difference (IV, Fixed, 95% CI) Subtotals only
4.1 < = 12 weeks 2 794 Mean Difference (IV, Fixed, 95% CI) 0.02 [‐0.06, 0.11]
4.2 > 12 weeks 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
5 Diary Card Symptom Score (night) change from baseline 2   Mean Difference (IV, Fixed, 95% CI) Subtotals only
5.1 < = 12 weeks 2 800 Mean Difference (IV, Fixed, 95% CI) 0.02 [‐0.06, 0.10]
5.2 >12 weeks 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
6 Rescue Medications (puffs per day) change from baseline 2   Mean Difference (IV, Fixed, 95% CI) Subtotals only
6.1 < = 12 weeks 2 788 Mean Difference (IV, Fixed, 95% CI) ‐0.11 [‐0.39, 0.17]
6.2 >12 weeks 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
7 Rescue Medications (puffs per night) change from baseline 2   Mean Difference (IV, Fixed, 95% CI) Subtotals only
7.1 < = 12 weeks 2 788 Mean Difference (IV, Fixed, 95% CI) ‐0.03 [‐0.12, 0.05]
7.2 >12 weeks 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
8 Withdrawal Due to Adverse Event 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
8.1 < = 12 weeks 2 301 Risk Ratio (M‐H, Fixed, 95% CI) 0.59 [0.14, 2.43]
8.2 > 12 weeks 0 0 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]