Comparison 16. High vs Low ICS Dose (Duration).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 FEV1	2		Std. Mean Difference (IV, Fixed, 95% CI)	Subtotals only
1.1 < = 12 weeks	2	123	Std. Mean Difference (IV, Fixed, 95% CI)	‐0.20 [‐0.55, 0.16]
1.2 > 12 weeks	0	0	Std. Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
2 Morning PEF (L/min)	2		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.1 < = 12 weeks	2	95	Mean Difference (IV, Fixed, 95% CI)	‐18.05 [‐56.04, 19.95]
2.2 > 12 weeks	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
3 Morning PEF (L/min) change from baseline	2		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
3.1 <= 12 weeks	2	282	Mean Difference (IV, Fixed, 95% CI)	12.00 [‐1.50, 25.51]
3.2 > 12 Weeks	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
4 Rescue Medications (no. of puffs)	2		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
4.1 < = 12 weeks	2	95	Mean Difference (IV, Fixed, 95% CI)	‐0.04 [‐0.65, 0.56]
4.2 > 12 weeks	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
5 Withdrawal Due to Adverse Event	2		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
5.1 < = 12 weeks	2	295	Risk Ratio (M‐H, Fixed, 95% CI)	0.56 [0.14, 2.33]
5.2 >12 weeks	0	0	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]