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. 2019 Feb 26;10(4):513–516. doi: 10.1039/c8md00562a

Table 2. Inhibitory activities of the synthesized probes against the hERG potassium channel.

Compd IC50 a (μM) K i b (μM)
N1 0.053 0.030
N2 0.183 0.103
N3 0.186 0.104
Astemizole 0.011 0.006

aSee ESI.

bThe inhibition constant (Ki) was calculated from each IC50 value using the Cheng–Prusoff equation.