Table 2. Synergy evaluation with 8 μg mL–1 peptide–levofloxacin conjugates 1–12 in combination with fluoroquinolones (FQ) against wild-type P. aeruginosa PAO1.
Conjugate | MIC (μg ml–1) of FQs in combination with 8 μg ml–1 conjugates |
||
Ciprofloxacin | Levofloxacin | Moxifloxacin | |
1 | 0.125 | 0.500 | 1 |
2 | 0.125 | 0.250 | 1 |
3 | 0.125 | 0.250 | 1 |
4 | 0.063 | 0.250 | 1 |
5 | 0.125 | 0.500 | 1 |
6 | 0.125 | 0.500 | 1 |
7 | 0.125 | 0.250 | 1 |
8 | 0.063 | 0.250 | 1 |
9 | 0.063 | 0.250 | 1 |
10 | 0.031 | 0.063 | 0.250 |
11 | 0.031 | 0.125 | 0.250 |
12 | 0.031 | 0.125 | 0.250 |
Antibiotic alone: | 0.125 | 0.500 | 1 |