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. Author manuscript; available in PMC: 2019 Apr 25.
Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2017 Dec 16;1864(3):746–757. doi: 10.1016/j.bbadis.2017.12.023

Fig. 4.

Fig. 4.

EC-proNGF overexpression triggers expression of p75NTR and inflammatory mediators in the retina. (a) Representative of Western Blot and statistical analysis of proNGF and actin from retina lysate showed a trend of increased proNGF but no significant difference in Cre-proNGF compared to Cre-controls (n = 3–4). (b) Representative of Western Blot and statistical analysis of systemic proNGF from serum samples showing no significant difference between Cre and Cre-proNGF animals (n = 4). (c & d) Quantitative real-time PCR showed a significant increase in retinal proNGF mRNA levels in Cre-proNGF group, while there is no change in retinal NGF levels among all groups. (*p < 0.05 vs WT, proNGF and Cre, n = 6–10). (e) Quantitative real-time PCR showing a significant increase of retinal p75NTR receptor mRNA level compared to controls (*p < 0.05 vs Cre and proNGF, n = 6–7).