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. Author manuscript; available in PMC: 2019 Apr 25.
Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2017 Dec 16;1864(3):746–757. doi: 10.1016/j.bbadis.2017.12.023

Fig. 8.

Fig. 8.

EC-proNGF overexpression induces albuminuria and RhoA activation. (a) Statistical analysis using One-Way ANOVA of Urine Albumin to Creatinine ratio showed significant increases in Cre-proNGF animals compared to controls (n = 5, *p < 0.05 vs WT and proNGF, #p < 0.05 vs Cre). (b) Real-time PCR of VEGF mRNA level from renal cortex showed no difference in VEGF levels among all groups (n = 5). (c) Pull down assay from renal lysate from Cre-proNGF showed significant increase in RhoA kinase activity in Cre-proNGF compared to Cre and proNGF alone. (*p < 0.05 vs Cre and proNGF controls, n = 4).