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. 2019 Apr 25;20:209. doi: 10.1186/s12859-019-2784-7

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© The Author(s) 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — A fitted energy model based on stacking pairs (a) leads to approximated free-energies that are highly correlated (R=0.99) with free-energies in the Turner energy model (b), yet induces tree widths that are amenable to practical sampling (c)