Table 3.

Association of the T cell activation status and mortality of breast cancer stratified by the BRCA1 expression level

Stratification		Death
Variable	Variable	HRa	95% CIb	p-value
Low BRCA1	T cell activation
	Exhaustion	1.00
	Intermediate	0.47	0.28–0.80	0.006
	Activation	0.43	0.20–0.93	0.031
	p-trend		0.011
	Age (per 5 years)	1.15	1.05–1.27	0.004
	Disease Stage	2.78	1.89–4.10	< 0.0001
	Histological type
	Ductal	1.00
	Lobular	0.54	0.29–1.00	0.048
	Mix	0.81	0.29–2.28	0.683
	Other	2.36	0.92–6.03	0.074
High BRCA1	T cell activation
	Exhaustion	1.00
	Intermediate	1.47	0.85–2.55	0.174
	Activation	0.53	0.20–1.43	0.211
	p-trend		0.640
	Age (per 5 years)	1.23	1.13–1.35	< 0.0001
	Disease Stage	2.07	1.45–2.96	< 0.0001
	Histological type
	Ductal	1.00
	Lobular	0.77	0.39–1.52	0.448
	Mix	0.68	0.25–1.87	0.450
	Other	2.79	1.09–7.13	0.032
P-value for the interaction between BRCA1 level and T cell activation			0.009

^aHR: adjusted hazard ratio, which was obtained from a multivariate Cox proportional hazards regression model

^bCI confidence interval