Table 4.

Association of the T cell activation status and mortality of breast cancer stratified by the CCND1 expression level

Stratification		Death
Variable	Variable	HRa	95% CIb	p-value
Low CCND1	T cell activation
	Exhaustion	1.00
	Intermediate	0.67	0.41–1.10	0.113
	Activation	0.39	0.19–0.81	0.011
	p-trend		0.008
	Age (per 5 years)	1.14	1.04–1.25	0.008
	Disease Stage	2.77	1.89–4.07	<.0001
	Histological type
	Ductal	1.00
	Lobular	0.61	0.34–1.12	0.109
	Mix	1.44	0.57–3.62	0.441
	Other	3.01	1.32–6.83	0.009
High CCND1	T cell activation
	Exhaustion	1.00
	Intermediate	1.34	0.73–2.47	0.352
	Activation	0.91	0.33–2.52	0.854
	p-trend		0.822
	Age (per 5 years)	1.26	1.15–1.38	<.0001
	Disease Stage	2.09	1.47–2.98	<.0001
	Histological type
	Ductal	1.00
	Lobular	0.69	0.35–1.36	0.281
	Mix	0.38	0.12–1.23	0.106
	Other	1.44	0.49–4.24	0.509
P value for the interaction between CCND1 level and T cell activation			0.135

^aHR: adjusted hazard ratio, which was obtained from a multivariate Cox proportional hazards regression model

^bCI confidence interval