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. 2019 Apr 25;7:59. doi: 10.1186/s40478-019-0704-8

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Gene set analysis associates the E- and M-subtypes with previous glioma expression and methylation signatures (see Additional file 1: Table S6 for details). The expression and methylation levels of the signature sets are shown as bar-code profiles where each bar refers to one sample. Correlation plots between expression and methylation levels in GSZ-scale reflect predominantly repressive effects of promoter methylation on the expression of the downstream genes (right part)