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. 2019 Apr 25;7:59. doi: 10.1186/s40478-019-0704-8

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Cell type, micro-environmental immune cell and treatment-resistance characteristics. a Heatmaps of expression and methylation levels of single-cell signatures taken from [59] reveal subtype-specific activation of astrocyte-, oligodendrocyte- and stem cell-like characteristics. b Digital immune cell-type decomposition of glioma transcriptomes using CIBERSORT [46] (see Fig. S21 for the full set of cells considered) on sample (above) and mean subtype levels for selected leukocyte cells across the expression subtypes. c The boxplots of expression and methylation levels of a transcriptomic drug and radiation resistance signature containing 50 genes [54] suggest largest resistance effects in E3 and E1. Expression and methylation levels of the subgroups anti-correlate (right part)