Table 1.

Main Outcome Measures in the RIVER Registry

Outcome	Category
Clinical events	Stroke (ischaemic and haemorrhagic)
	Transient ischaemic attack
	Peripheral/non-central nervous system embolism
	Pulmonary embolism
	Heart failure
	Myocardial infarction
	Hospitalization
	Sudden cardiac death
	Non-cardiovascular death
Bleeding events
Severity	Major
	Non-major clinically relevant
	Minor
Location	Intracranial
	Ears, nose, throat
	Gastrointestinal
	Genitourinary
	Vascular access site
Outcome	Recovered
	Permanently disabled
	Fatal
Healthcare utilization used for bleeding event	Hospitalization
	Emergency room visit
	Surgery for bleeding
	Transfusion
	Physician consultation
Therapy persistence	Rate of discontinuation
	Duration of time on therapy
	Reasons for discontinuation
Hospitalization for any event
Any other hospital visits	Inpatient, outpatient, and emergency room
Patients treated with vitamin K antagonists	Frequency and timing of monitoring
	INR recordings in relation to therapeutic range
	Location of testing (self-monitoring, general practitioner clinic, anticoagulant clinic, etc.)
	Dose adjustments
	Use of bridging anticoagulation necessitated by interruption of vitamin-K antagonist
	Outcomes in relation to INR fluctuation
Patients treated with additional antithrombotic therapy	Therapy changes (discontinuation, temporary interruptions and use of bridging therapy)
	Reasons of therapy changes (if applicable)
	Patient treatment satisfaction using the Anti-Clot Treatment Scale (ACTS), depending on the cohort and country (at 4, 12, 24 months)

INR International normalise ratio