Table 1.
Baseline characteristics of the included studies
| Reference | Year | Study design | Age (years)a | GA (weeks)a | No. of Women | Negative appendectomy (%) | Complicated appendicitis (%) | Outcomes | ||
|---|---|---|---|---|---|---|---|---|---|---|
| Total | LA | OA | ||||||||
| Yoo et al. [16] | 2016 | Retrospective | 30.8 | 20.2 | 80 | 24 | 56 | NA | 31.3 | Fetal loss, preterm delivery, LOS, operative time, birth weight, wound infection, intraabdominal abscess |
| Karaman et al. [17] | 2016 | Retrospective | 22.8 | 24.9 | 48 | 12 | 36 | NA | NA | Fetal loss, preterm delivery, LOS, operative time, Apgar score, birth weight, wound infection, intraabdominal abscess |
| Cox et al. [30] | 2016 | Retrospective | 27.9 | NA | 1335 | 894 | 441 | NA | 9.0 | Operative time, wound infection, LOS, intraabdominal abscess |
| Cheng et al. [18] | 2015 | Retrospective | NA | NA | 781 | 128 | 653 | NA | 15.5 | Fetal loss, preterm delivery, LOS |
| Peled et al. [19] | 2014 | Retrospective | 28.1 | 17.9 | 85 | 26 | 59 | 17.6 | 12.9 | Fetal loss, preterm delivery, LOS, Apgar score, birth weight, |
| Kapan et al. [31] | 2013 | Retrospective | 26.2 | 17.5 | 17 | 7 | 10 | NA | NA | Fetal loss, LOS, operative time, |
| Chung et al. [20] | 2013 | Retrospective | 30.6 | 16.6 | 61 | 22 | 39 | 9.8 | 11.5 | Fetal loss, preterm delivery, LOS, operative time, Apgar score, birth weight, wound infection, intraabdominal abscess |
| Miloudi et al. [32] | 2012 | Retrospective | NA | NA | 27 | 16 | 11 | NA | 14.8 | Fetal loss |
| Khan et al. [21] | 2012 | Retrospective | 22.8 | 17.3 | 118 | 52 | 66 | NA | NA | Fetal loss, preterm delivery, LOS, operative time, wound infection, intraabdominal abscess |
| Jung et al. [22] | 2012 | Retrospective | 27.9 | 15.4 | 25 | 4 | 21 | 0 | NA | Fetal loss, preterm delivery, LOS, wound infection |
| Eom et al. [23] | 2012 | Retrospective | 29.1 | 38.7 | 43 | 15 | 28 | 0 | 23.3 | Fetal loss, preterm delivery, LOS, operative time, birth weight, intraabdominal abscess |
| De Bakker et al. [24] | 2011 | Retrospective | NA | NA | 15 | 12 | 3 | 3.0 | NA | Fetal loss, preterm delivery, LOS, operative time |
| Sadot et al. [25] | 2010 | Retrospective | 29.5 | 19.7 | 65 | 48b | 17b | 24.1 | 12.3 | Fetal loss, preterm delivery, LOS, operative time, Apgar score, birth weight, wound infection |
| Corneille et al. [26] | 2010 | Retrospective | 25.6 (6.4) | 15.9 (8.4) | 49 | 9 | 40 | NA | NA | Fetal loss, preterm delivery, LOS |
| Kirshtein et al. [3] | 2009 | Retrospective | 28.4 | 13.9 (6.0) | 42 | 23 | 19 | 42.9 | 19.0 | Fetal loss, LOS, operative time, Apgar score, birth weight, wound infection |
| Upadhyay et al. [33] | 2007 | Prospective | 27.2 (3.3) | 32 (2.6) | 6 | 4 | 2 | NA | NA | Fetal loss, preterm delivery |
| McGory et al. | 2007 | Retrospective | 27.2 (6.0) | NA | 3133 | 454 | 2679 | 23.1 | 25.3 | Fetal loss |
| Carver et al. [34] | 2005 | Retrospective | 23.4 (5.8) | 14 (5.4) | 28 | 17 | 11 | NA | NA | Fetal loss, preterm delivery, LOS, Apgar score, birth weight, wound infection |
| Lyass et al. [36] | 2001 | Prospective | 28.5 (15.2) | 20 (6.3) | 22 | 11 | 11 | 31.8 | 0 | Fetal loss, preterm delivery, LOS, operative time |
| Affleck et al. [37] | 1999 | Retrospective | NA | NA | 37 | 19 | 18 | NA | NA | Fetal loss, preterm delivery |
| Gurbuz et al. [38] | 1997 | Prospective | 24.5 (1.5) | 20.1 (9.0) | 9 | 5 | 4 | NA | NA | Fetal loss, preterm delivery, LOS, operative time |
| Curet et al. [39] | 1996 | Retrospective | NA | NA | 11 | 4 | 7 | NA | NA | Fetal loss |
aValues are the means (standard deviations)
bMissing data, 41 vs 16
NA not available, GA gestational age, LA laparoscopic appendectomy, OA open appendectomy, LOS length of stay