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. 2019 Apr 18;10:433. doi: 10.3389/fphys.2019.00433

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Copyright © 2019 Li, Sun, Drummer, Lu, Yu, Zhou, Li, Pearson, Johnson, Yu, Yang, Mastascusa, Jiang, Sun, Rogers, Hu, Wang and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Lysophosphatidylcholine (LPC)-induced top 5% significantly changed circular RNAs (circRNAs) are studied in human aortic endothelial cells (HAECs) in comparison to that of control HAECS. This is a flow chart to outline how we analyzed the 5% top significantly changed circular RNAs from LPC-treated HAECs in comparison to that from control HAECs. (B) The majority (48 out of 51,94.1%) of circRNA expression increases while related mRNA expressions remain constant or decrease. (C) There is no significant differences in exon numbers among circRNA groups. (D) There are no overlaps among the top 10 pathways in the following four groups.