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. 2019 Apr 18;10:433. doi: 10.3389/fphys.2019.00433

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Copyright © 2019 Li, Sun, Drummer, Lu, Yu, Zhou, Li, Pearson, Johnson, Yu, Yang, Mastascusa, Jiang, Sun, Rogers, Hu, Wang and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) CircRNA has the potential role to inhibit type 2 diabetes mellitus (T2DM)by sponging miRl43 and preventing miRl43 from binding to oxysterol-binding protein-related protein 8 (ORP8) ˆuntranslated region (3′UTR). (B) Upregulated circRNAs sponge miRNAs involved in both pro- and anti-inflammatory pathways. (C) Downregulated circRNAs sponge miRNAs are involved with both pro-inflammatory and anti-inflammatory pathways. (D) One pathway is overlapped in the sponged microRNAs between upregulated and downregulated circRNAs.