. Author manuscript; available in PMC: 2020 Mar 15.

Published in final edited form as: J Org Chem. 2019 Feb 27;84(6):3249–3259. doi: 10.1021/acs.joc.8b03162

Table 2. Substrate scope for the synthesis of 4-chloropiperidines.^a.

1 (0.2 mmol), HCl•DMPU (2.4 equiv), DMSO (2.4 equiv), 65 °C, 9–24 h. All yields are isolated yields.

Table 2. Substrate scope for the synthesis of 4-chloropiperidines.a.