Table 1:
FXTAS clinical and molecular findings.
| Medical History/Clinical Findings | Age at Onset of Symptoms (years) |
|---|---|
| Generalized Anxiety | 10 |
| Bulimia | 14 |
| Migraines | 16 |
| FXPOI | 27 |
| Major Depressive Disorder | 30 |
| Dizziness and vertigo | 34 |
| Hypotdyroidism | 34 |
| Fibromyalgia | 34 |
| Chronic Pain | 34 |
| Tingling and numbness | 39 |
| Memory problems | 47 |
| Handwriting problems | 47 |
| Balance problem | 47 |
| Swallowing problem | 47 |
| Tremor | 48 |
| Hearing loss | 53 |
| Neurological Exam | Severity of Symptoms |
| Right upper extremity | Intention tremor (+++) |
| Postural tremor (++) | |
| Intention tremor(+) | |
| Left upper extremity | Postural tremor (+) |
| Molecular Tests | Results |
| Fragile X DNA test (CGG repeats) | 93 |
| FMR1 mRNA level (times normal) | 3.71 |
| Diagnosis | |
| FXTAS diagnosis | Probable |
| FXTAS stage | 4 |