Table 2. Cell growth inhibition of compounds which demonstrated activity towards cell line which are dependent on hDM2, hDMX or both, demonstrated by the MTS assay a .
SJSA-1 IC50 (μM) | A549 IC50 (μM) | HCT116 IC50 (μM) | MCF-7 IC50 (μM) | JEG3 IC50 (μM) | |
5 | >100 | 16.2 ± 0.06 | 20.5 ± 0.07 | 29.8 ± 0.13 | 35.5 ± 0.10 |
10 | 30.0 ± 2.29 | 65.7 ± 0.22 | >100 | >100 | 38.1 ± 0.03 |
aIC50 values determined by non-linear regression of at least three experiments (see ESI,† pg 13). Errors are the transformed greater extreme of the standard error.