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. 2019 Mar 22;10(16):4502–4508. doi: 10.1039/c9sc00059c

Table 2. Cell growth inhibition of compounds which demonstrated activity towards cell line which are dependent on hDM2, hDMX or both, demonstrated by the MTS assay a .

SJSA-1 IC50 (μM) A549 IC50 (μM) HCT116 IC50 (μM) MCF-7 IC50 (μM) JEG3 IC50 (μM)
5 >100 16.2 ± 0.06 20.5 ± 0.07 29.8 ± 0.13 35.5 ± 0.10
10 30.0 ± 2.29 65.7 ± 0.22 >100 >100 38.1 ± 0.03

aIC50 values determined by non-linear regression of at least three experiments (see ESI,† pg 13). Errors are the transformed greater extreme of the standard error.