Table 2.
Individual Aggregation-Induced Reprogramming Values for: Glucose Consumption and Lactate Production Rates, Yield of Lactate from Glucose
| Aggregate size | Treatment | Glucose consumed (pmol/cell/day) | Lactate produced (pmol/cell/day) | Glycolytic yield (mol/mol) | |||
|---|---|---|---|---|---|---|---|
| Mean | Significance | Mean | Significance | Mean | Significance | ||
| 10k | a-Control | 14.0 ± 0.4 | c,d | 24.8 ± 0.7 | b,c,d | 1.8 ± 0.0 | b,c |
| b-SF1670 | 15.6 ± 0.3 | a,c,d | 19.2 ± 0.5 | a,c,d | 1.2 ± 0.0 | a,c,d | |
| c-Wortmannin | 7.4 ± 0.3 | a,b | 6.2 ± 0.3 | a,b,d | 0.8 ± 0.1 | a,b,d | |
| d-Y27632 | 6.2 ± 0.7 | a,b | 9.2 ± 0.8 | a,b,c | 1.5 ± 0.3 | b,c | |
| 30k | a-Control | 8.0 ± 0.2 | b,c,d | 14.6 ± 0.6 | b,c,d | 2.0 ± 0.0 | b,c,d |
| b-SF1670 | 12.2 ± 0.0 | a,c,d | 17.3 ± 0.1 | a,c,d | 1.4 ± 0.0 | a,c | |
| c-Wortmannin | 6.0 ± 0.2 | a,b,d | 4.5 ± 0.0 | a,b,d | 0.7 ± 0.0 | a,d | |
| d-Y27632 | 4.3 ± 0.2 | a,b,c | 6.3 ± 0.4 | a,b,c | 1.5 ± 0.1 | a,b,c | |
| 50k | a-Control | 6.1 ± 0.9 | b,d | 9.0 ± 1.0 | b,c,d | 1.9 ± 0.1 | b,c |
| b-SF1670 | 11.3 ± 0.1 | c,d | 16.7 ± 0.0 | a,c,d | 1.5 ± 0.0 | a,c | |
| c-Wortmannin | 4.5 ± 0.2 | a,b,d | 3.2 ± 0.1 | a,b | 0.7 ± 0.0 | a,b,d | |
| d-Y27632 | 2.2 ± 0.1 | a,b,c | 3.1 ± 0.2 | a,b | 1.4 ± 0.2 | c | |
Significance connects the given row to the appropriate lettered row: (a) untreated control, (b) SF1670 treated, (c) Wortmannin treated, and (d) Y27632 treated. Data represent the mean of at least three independent determinations; errors represent the standard error in the mean.