Table 2.
Ordinary Least Squares Regression Model of NAD+ Metabolite Abundance by Age
| Metabolite | B Age* | r2 | F | p | SD |
|---|---|---|---|---|---|
| NAD+ | −0.040 | 0.86 | 167.2 | 4.4E-13 | 20.2 |
| NAAD | −0.016 | 0.10 | 4.06 | 5.4E-02a | 3.98 |
| NAM | 0.023 | 0.24 | 10.25 | 3.5E-03 | 11,829 |
| MeNAM | 0.028 | 0.39 | 18.88 | 1.7E-04 | 12.9 |
| ADPR | 0.017 | 0.13 | 5.22 | 3.0E-02 | 2.29 |
| NADP+ | −0.025 | 0.31 | 13.46 | 1.0E-03 | 1.33 |
| NADPH | 0.027 | 0.34 | 15.38 | 5.4E-04 | 1.97 |
*
metabolite abundances were standardized, so that B Age represents the slope in standard deviation (SD) units.
a
model trended towards significance p < 0.1.
ADPR, adenosine diphosphate ribose; MeNAM, N-methyl-nicotinamide; NAAD, nicotinic acid adenine dinucleotide; NAD+, nicotinamide adenine dinucleotide; NAM, nicotinamide.