Skip to main content
. 2019 Mar 21;4(6):e122686. doi: 10.1172/jci.insight.122686

Figure 7. Myotonic dystrophy type 1 iPSC–derived cardiomyocytes are characterized by MBNL foci.

Figure 7

iPSC-derived cardiomyocytes were immunostained with an antibody to the splicing factor MBNL1 (green), and nuclei were labeled with Hoechst (blue). DM1 cardiomyocytes had readily detectable MBNL1-positive intranuclei foci (middle panel, white arrows) and reduced nucleoplasmic MBNL staining compared with control and DM2 cardiomyocytes. These findings support that MBNL1 sequestration characterizes DM1 but not DM2. Higher-magnification images of the white dotted boxes are shown on the right. Scale bar: 50 μm (left); 10 μm (right).