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. 2019 Mar 21;4(6):e122686. doi: 10.1172/jci.insight.122686

Figure 9. RNA splicing profiles distinguish DM1- and DM2 iPSC–derived cardiomyocytes.

Figure 9

(A and B) RNA from iPSC-derived cardiomyocytes was isolated and used for RT-PCR to measure specific splicing events. The SCN5A and ANK3 transcripts revealed an increase in embryonic transcripts from DM1 cardiomyocytes compared with cardiomyocytes from healthy control and DM2 subjects. In DM1, specific splicing events in the RYR2 and TNNT2 transcripts were significantly different from healthy control cardiomyocytes, and variability was observed for DM2 cardiomyocytes. *P < 0.05, 1-way ANOVA. Each lane in A indicates a study subject. **P = 0.006.