Table 3.

Animal characteristics and heart morphology

		HFREF
	Sham (WT)	WT	ASMase−/−
Infarct area, %		29 ± 9	41 ± 10†
Body weight, g	35 ± 2	36 ± 5	37 ± 9
LV weight, mg	117 ± 12	184 ± 43*	235 ± 35*
RV weight, mg	24 ± 4	37 ± 10†	47 ± 9*

Values are means ± SD; WT sham: n = 4 mice; HFREF animals: n = 3 mice/group. ASMase^−/−, acid sphingomyelinase knockout; HFREF, heart failure with reduced ejection fraction; LV, left ventricle; RV, right ventricle; WT, wild type.

^*Significantly different (P < 0.05) from WT sham;

^†P = 0.07 vs. WT sham.