Table 5.
The mRNA levels of genes involved in lipogenesis and triglyceride secretion in chow- and HMD-fed and HMD + soluble epoxide hydrolase inhibitor (TPPU) mice liver
| Lipid Metabolism Genes | Chow | HMD | HMD + TPPU |
|---|---|---|---|
| Lipogenesis | |||
| Lxrα | 1 ± 0.04 | 0.91 ± 0.06 | 0.96 ± 0.04 |
| Fas | 1 ± 0.18 | 0.84 ± 0.15 | 0.98 ± 0.14 |
| Acc | 1 ± 0.09 | 0.84 ± 0.11 | 0.86 ± 0.04 |
| Srebp1 | 1 ± 0.14 | 0.77 ± 0.09 | 0.75 ± 0.12 |
| Chrebp | 1 ± 0.10 | 1.01 ± 0.09 | 1.10 ± 0.12 |
| Triglyceride secretion | |||
| ApoB | 1 ± 0.09 | 0.88 ± 0.11 | 1.04 ± 0.16 |
| Mtp | 1 ± 0.11 | 0.95 ± 0.10 | 1.04 ± 0.13 |
Values are means ± SE; n = 5 for chow diet; n = 7 for high-metnionine diet (HMD); and n = 8 for HMD + 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU). C57BL/6 mice were fed a chow diet or HMD for 8 wk with or without TPPU in drinking water (0.8 mg·kg−1·day−1) for 4 wk.