Fig. 5.

U0126 treatment suppresses activation of Notch1/Jagged-1 signaling pathway in the kidney of hyperuricemic rats. HN, hyperuricemic nephropathy. A: kidney tissue lysates were subjected to immunoblot analysis with specific antibodies against Notch1, Jagged-1, and GAPDH. B: expression level of Notch1 was quantified by densitometry and normalized to GAPDH. C: expression level of Jagged-1 was quantified by densitometry and normalized to GAPDH. Data are presented as means ± SE (n = 6). Means with different superscript letters are significantly different from one another (P < 0.05).