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Glucocorticoid effects on p21 mRNA and protein expression. Administration of dexamethasone (DXM) to control (C) (normal) mice increased p21 mRNA and protein levels >10-fold within 4 h. DXM also evoked ~2- to 3-fold increases in p21 mRNA and protein levels 4 h after glycerol injection. These changes were observed despite slight decreases, rather than increases, in p53 mRNA levels over this 4-h time period. Values are means ± SE; n = 5–8 mice per group.
