Fig. 4.
Gq-designer receptors exclusively activated by designer drugs (DREADD) is restrictively expressed in principal cells of the PC-Gq-DREADD mouse. Shown are representative fluorescence micrographs of cortical renal sections from two PC-Gq-DREADD mice (top and middle) and one littermate control mouse (floxed; bottom) stained with anti-green fluorescent protein antibody (red; left) identifying mCitrine and anti-aquaporin 2 (AQP2) antibody (green; middle). Merged images are shown at right. For presentation purposes, sharpness, contrast, and brightness were adjusted to maximize clarity without changing content.