Table 1.
Long non-coding RNAs involved in diabetic nephropathy
| Cell type | LncRNA | Cell function | Potential targets | ref |
|---|---|---|---|---|
| mouse mesangial cell | CYP4B1-PS1-001 | overexpression of CYP4B1-PS1-001 inhibited proliferation and fibrosis of mesangial cells | PCNA,cyclin-D1,Col 1,Fibronectin | 86 |
| ENSMUST-00000147869 | Reduce cell proliferation, decreased the synthesis of fibronectin and collagen I | PCNA,cyclin-D1,Col 1, Fibronectin | 87 | |
| Gm4419 | Regulate the pro-inflammatory and fibrosis cytokines and mesangial cell proliferation | NF-kB/NRLP3 | 88 | |
| lincRNA 1700020I24Rik | affect cell proliferation and expressions of renal fibrosis markers | miR-34a-5p/Sirt1/HIF-1α | 89 | |
| human mesangial cell (HMC) | Lnc-MGC | inhibit the expression of key cluster miRNAs in the kidney, and regulate TGF-β signaling, cellular hypertrophy, extracellular matrix synthesis and ER stress. | PTEN,CUGBP2,PUM2, TNRC6B,CPEB4, BHC80,EDEM3, ATF3 and others | 81 |
| ASncmtRNA-2 | TGF-b and FN expression were up regulated by HG-induced ASncmtRNA-2 in HMC | TGF-b | 90 | |
| PVT1 | FN1, COL4A,TGFB1,PAI-1 expression were decreased in HMC treated with high glucose | FN1, COL4A,TGFB1,PAI-1 | 91 | |
| podocyte | Lnc TUG1 | modulates mitochondrial bioenergetics through PGC-1a in podocyte | peroxisome proliferator–activated receptor g coactivator a (PGC-1 a) | 82 |
| Linc01619 | regulates miR-27a/FOXO1 mediated ER stress and podocyte apoptosis | miR 27a/FOXO1 | 85 | |
| ENSRNOG00000037522 | inhibit the high glucose-induced podocyte epithelial mesenchymal transition | PODXL-1,nephrin | 92 | |
| MALAT1 | MALAT1 regulated by b-catenin, MALAT1 knock-down rectified podocyte damage via down-regulating SRSF1 overexpression | SRSF1 | 93 | |
| Gm5524 Gm15645 |
Affect autophagy and apoptosis of podocyte | Atg5,Atg7,Bcl2 | 98 | |
| HK2 | MALAT1 | Down regulated MALAT1 decreased the expression of the pro-inflammatory cytokines IL-6 and TNF-α | ELAVL1, NLRP3, Caspase-1, TNF-a, IL-1β ,IL-6 | 94,95 |
| MIAT | regulated HK2 cell viability via stabilizing Nrf2 expression | Nrf2 | 96 | |
| Lnc ZEB1-AS1 | Inhibition of lnc ZEB1-AS1 may increase HG-induced ECM accumulation by downregulating ZEB1 expression | ZEB1 | 97 | |
| tubular epithelial cell (TEC)/mouse mesangial cell (MMC) | Erbb4-IR | Regulate the collagen expression in TEC and MMC through miR29b | miR29b | 83 |