Table 1.
Summary of studies comparing different GLP1 RAs included in the review
| Country | n | Population characteristics | Participant recruitment | Preference evaluation | Survey administration | Comparators | |
|---|---|---|---|---|---|---|---|
| Gelhorn et al18 | UK | 243 | T2DM, injection-naïve, mean age 60.5±10.9 years, 76.1% male | Newspaper/internet/classified advertisements | DCE | Administration by trained moderator of patient self-completed questionnaires | Dulaglutide QW Liraglutide QD |
| Gelhorn et al19 | Japan | 182 | T2DM, injection-naïve, mean age 58.9±10.0 years, 64.3% male | Advertisement on closed online clinical volunteer database | DCE | Administration by trained moderator of patient self-completed questionnaires | Dulaglutide QW Liraglutide QD |
| Hauber et al20 | USA | 643 | T2DM, injection-experienced and injection-naïve, mean age 52.7±15.0 years, 57.1% male | Existing T2DM ailment panel | DCE | Online self-administered survey | Liraglutide QD Exenatide QW |
| Jendle et al24 | Sweden | 461 | T2DM, age/sex NR | Existing email panel | WTP | Online self-administered survey | Liraglutide QD Exenatide BID |
| Matza et al12 | UK | 209 | T2DM, injection-experienced and injection-naïve, mean age 60.4±8.9 years, 57.4% male | Newspaper/online advertisements, fliers near interview sites, patient advocacy group newsletters | TTO | One-to-one interviews | QW GLP1 RA injections |
| Matza et al21 | Italy | 238 | T2DM, injection-experienced and injection-naïve, mean age 60.2±9.3 years, 58.8% male | Database of previous study volunteers | TTO | One-to-one interviews | QW GLP1 RA injections |
| Polster et al22 | USA | 382 | T2DM, injection-experienced and injection-naïve, mean age 53.0±8.75 years, 48.0% male | Online web panel | TTO DCE | Online self-administered survey | Liraglutide QD Exenatide BID |
| Qin et al15 | Brazil, China, Germany, Japan, UK | 1,482 | T2DM, injection-naïve, mean age 56.0±11.4 years, 68.0% male | Patient databases, referrals from clinicians and patient associations, targeted publication advertisements | DCE | Online self-administered survey | Liraglutide QD Exenatide QW |
| Qin et al23 | Germany, UK | 510 | T2DM, injection-experienced, mean age 57.0±11.0 years, 51.4% male | Patient databases, referrals from clinicians and patient associations, targeted publication advertisements | DCE | Online self-administered survey | Liraglutide QD Exenatide QW |
Abbreviations: BID, bis in die (twice daily); DCE, discrete-choice experiment; NR, not reported; QD, quaque die (once daily); QW, once weekly; RAs, receptor agonists; T2DM, type 2 diabetes mellitus; TTO, time trade-off; WTP, willingness to pay.