Table 3.
Unadjusted and Adjusted ORs for Phylogenetically Corroborated Transmission Events vs no Transmission (GEE Analyses) Among 101 Prospectively Followed Young PWID Partnerships
| Characteristic | Unadjusted OR (95% CI) | Adjusted OR (95% CI) |
|---|---|---|
| Demographics (at enrollment) | ||
| Race of at-riska partner = nonwhite | 0.52 (0.15–1.84) | |
| Age of at-riska partner | 1.01 (0.86–1.19) | |
| Age difference of partnership, y | 0.93 (0.84–1.03) | |
| Gender composition of partnership | ||
| Male/male or female/female | Ref | Ref |
| Male at-riska/female indexb | 7.12 (1.14–44.44) | 1.91 (0.17–21.10) |
| Female at-riska/male indexb | 1.97 (0.50–7.84) | 0.29 (0.01–6.33) |
| Duration of partnership, mo | 0.97 (0.95–1.01) | |
| Injecting and sexual behaviors (time updated) | ||
| No. of days the partners injected together, past month | 1.11 (1.05–1.17) | 1.07 (1.01–1.14) |
| Any receptive needle sharing by at-riska partner with indexb partner, prior month = yes | 1.44 (0.14–14.82) | |
| Ancillary equipment sharing at all instances of the partners injecting together, prior month = yes | 4.87 (1.45–16.35) | 5.32 (1.25–22.70) |
| Median No. of other injecting partners of the at-riska partner | 1.01 (1.00–1.03) | |
| Partners had sexual relationship, prior month = yes | 9.74 (2.40–39.48) | 7.77 (0.58–103.52) |
| HCV characteristics of indexb partner (time updated) | ||
| Indexb partner in HCV-seronegative viremic phasec | 14.84 (2.77–79.48) | 28.02 (5.61–139.95) |
| HCV viremia of indexb partner nearest visit (log10) | 1.03 (0.69–1.53)d | 0.90 (0.55–1.46)d |
Bold indicates statistical significance (P < .05).
Abbreviations: CI, confidence interval; GEE, generalized estimating equation; HCV, hepatitis C virus; OR, odds ratio; PWID, people who inject drugs.
aAt-risk partner: enrolled as either HCV RNA negative or HCV-seronegative viremic.
bIndex partner: enrolled as HCV RNA positive.
cHCV-seronegative viremic phase: indicated by anti-HCV-negative and HCV RNA–positive test results, as well as RNA-positive test results.
dLast value carried forward.