Comparison 2. Biperiden plus pilocarpine versus no treatment.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Salivary flow rate (unstimulated)	1		Mean Difference (IV, Random, 95% CI)	Subtotals only
1.1 End of radiotherapy	1	40	Mean Difference (IV, Random, 95% CI)	0.02 [‐0.08, 0.12]
1.2 Up to and including 3 months postradiotherapy	1	17	Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
2 Salivary flow rate (> 0 g) unstimulated	1		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1 End of radiotherapy	1	60	Risk Ratio (M‐H, Random, 95% CI)	1.11 [0.77, 1.58]
2.2 Up to and including 3 months postradiotherapy	1	60	Risk Ratio (M‐H, Random, 95% CI)	7.50 [1.88, 29.99]
2.3 Up to and including 6 months postradiotherapy	1	60	Risk Ratio (M‐H, Random, 95% CI)	29.00 [1.81, 465.07]
2.4 Up to and including 12 months postradiotherapy	1	60	Risk Ratio (M‐H, Random, 95% CI)	35.00 [2.20, 556.71]