| Study | Reason for exclusion |
|---|---|
| Anné 2002 | Not an RCT ‐ compares a subcutaneous amifostine group with the intravenous amifostine and no‐treatment arms from another study (Brizel 2000) |
| Bagga 2007 | Abstract; insufficient information |
| Bakowski 1978 | CCT |
| Belcaro 2008 | Not head and neck cancer patients |
| Bohuslavizki 1998 | Radioactive iodine not radiotherapy |
| Borg 2007 | Abstract; insufficient information |
| Bourhis 2000 | Salivary gland dysfunction was not a reported outcome |
| Braaksma 2002 | Data unavailable for the outcomes of interest to this review |
| Braaksma 2005 | Salivary gland dysfunction was not a reported outcome |
| Chambers 2005 | Abstract; insufficient information |
| Demiroz 2012 | Not an RCT |
| Fallahi 2013 | Radioactive iodine not radiotherapy |
| Fan 2011 | Unclear whether this is an RCT or not. Study authors contacted February 2016 but no reply received |
| Franzén 1995 | Salivary gland dysfunction was not a reported outcome |
| Fuertes 2004 | Quasi‐randomised trial (case history number) |
| Goyal 2007 | Abstract; insufficient information |
| Gu 2014 | Abstract; insufficient information |
| Johnson 2002 | Not an RCT |
| Karacetin 2004 | Quasi‐randomised trial |
| Koukourakis 2000 | No formal assessment of salivary gland dysfunction; data not presented for head and neck cancer patients |
| Kumarchandra 2010 | Abstract; insufficient information |
| Manoor 2014 | Abstract; insufficient information |
| Mateos 2001 | Quasi‐randomised trial (alternate assignment) |
| Mitine 2000 | Abstract; insufficient information |
| Mix 2013 | Abstract; insufficient information |
| Nicolatou‐Galitis 2003 | Not an RCT |
| Norberg‐Spaak 1996 | Abstract; insufficient information |
| Norberg‐Spaak 1997 | Abstract; insufficient information |
| Nyárády 2006 | Quasi‐randomised trial (alternate assignment) |
| Park 2012 | Abstract; insufficient information |
| Park 2012a | Abstract; insufficient information |
| Peters 1999 | Quasi‐randomised trial (day of birth) |
| Qian 2003 | Dissertation; unable to obtain a copy |
| Resubal 2011 | Abstract; insufficient information |
| Rieger 2012 | Control group not relevant for this review |
| Rischin 2010 | Tirapazamine is cancer treatment drug not a radiation protector |
| Rudat 2005 | Abstract; insufficient information |
| Schönekäs 1999 | Not an RCT |
| Sharma 2012 | Intervention not defined as a pharmacological agent |
| Strnad 1997 | Abstract; insufficient information |
| Su 2006 | Salivary gland dysfunction measured as an adverse event following administration of G‐CSF |
| Takahashi 1986 | Not an RCT |
| Thorstad 2003 | Not an RCT |
| Uchiyama 2005 | Unclear whether this is an RCT or not |
| Zale 1993 | Abstract; insufficient information |
| Zimmerman 1997 | Not an RCT |
CCT = controlled clinical trial; G‐CSF = granulocyte‐colony stimulating factor; RCT = randomised controlled trial.