Database	Time span	Search strategy
Cochrane Hepato‐Biliary Group Controlled Trials Register	May 2017.	(((benzodiazepine receptor OR GABA) AND (antagonist* OR blocking agent*)) OR flumazenil OR flumazepil)
Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library	2017, Issue 2.	#1 MeSH descriptor: [GABA Antagonists] explode all trees #2 MeSH descriptor: [Flumazenil] explode all trees #3 ((benzodiazepine receptor or GABA) and (antagonist* or blocking agent*)) or flumaze*il #4 #1 or #2 or #3 #5 MeSH descriptor: [Liver Cirrhosis] explode all trees #6 MeSH descriptor: [Hepatic Encephalopathy] explode all trees #7 liver cirrhosis or hepatic encephalopathy #8 #5 or #6 or #7 #9 #4 and #8
MEDLINE Ovid	1946 to May 2017.	1. exp GABA Antagonists/ 2. exp Flumazenil/ 3. (((benzodiazepine receptor or GABA) and (antagonist* or blocking agent*)) or flumaze*il).mp. [mp=protocol supplementary concept, rare disease supplementary concept, title, original title, abstract, name of substance word, subject heading word, unique identifier] 4. 1 or 2 or 3 5. exp Liver Cirrhosis/ 6. exp Hepatic Encephalopathy/ 7. (liver cirrhosis or hepatic encephalopathy).mp. [mp=protocol supplementary concept, rare disease supplementary concept, title, original title, abstract, name of substance word, subject heading word, unique identifier] 8. 5 or 6 or 7 9. 4 and 8 10. (random* or blind* or placebo* or meta‐analysis).mp. [mp=protocol supplementary concept, rare disease supplementary concept, title, original title, abstract, name of substance word, subject heading word, unique identifier] 11. 9 and 10
Embase Ovid	1974 to May 2017.	1. exp benzodiazepine receptor blocking agent/ 2. exp 4 aminobutyric acid receptor blocking agent/ 3. exp FLUMAZENIL/ 4. (((benzodiazepine receptor or GABA) and (antagonist* or blocking agent*)) or flumaze*il).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer] 5. 1 or 2 or 3 or 4 6. exp liver cirrhosis/ 7. exp hepatic encephalopathy/ 8. (liver cirrhosis or hepatic encephalopathy).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer] 9. 6 or 7 or 8 10. 5 and 9 11. (random* or blind* or placebo* or meta‐analysis).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer] 12. 10 and 11
Science Citation Index Expanded (Web of Science)	1900 to May 2017.	#5 #4 AND #3 #4 TS=(random* or blind* or placebo* or meta‐analysis) #3 #2 AND #1 #2 TS=(liver cirrhosis or hepatic encephalopathy) #1 TS=(((benzodiazepine receptor or GABA) and (antagonist* or blocking agent*)) or flumaze*il)
LILACS (Bireme)	1982 to May 2017.	(benzodiazepine receptor or GABA) and (antagonist$ or blocking agent$)) or flumaze$ [Words] and hepatic encephalopath$ [Words]