Conte 1994.

Methods	Active vs control Pain measurement tool: 6‐point scale. Patient reported Definition of pain response: a. Some improvement: improvement by 1 point over 2 consecutive reports or by 2 points in 1 report b. Marked improvement: improvement by 2 points over at least 2 consecutive reports
Participants	Breast cancer, no previous chemotherapy Bone metastases required Pain not required. Co‐intervention: chemotherapy Performance status criteria: no specifications Other criteria: none
Interventions	1. Active arm: Pamidronate Intravenous 45 mg every 3 weeks Indefinitely until toxicity or progressive bone disease 143 pts 2. Control arm: No additional intervention 152 pts All patients received chemotherapy, standardized for each participating institution
Outcomes	1. Pain: a. Proportion of patients with reduced pain No pain: 80/131 pamidronate 70/134 control Marked improvement: 54/131 pamidronate 38/134 control 2. Analgesic: stated is a secondary endpoint but no data /outcome reported Withdrawals Active arm: 6/143 Control arm: 6/152 Adverse reactions Active arm: Local reaction: 13 Fever: 8 Rigors: 2 Headache: 4 Musculoskeletal pain: 6 Hypocalcemia: 23 Control arm: Local reaction: 7 Fever 4 Rigors 0 Headache: 5 Musculoskeletal pain: 22 Hypocalcemia: 9
Notes	QS = 1