Delmas 1982a.

Methods	Active vs placebo control Pain measurement tool: 0‐9 point scale based on severity and duration Pain score expressed by: patient and physician
Participants	1. Multiple myeloma 2. Bone involvement not specified 3. Pain not required 4. Co‐intervention: chemotherapy 5. Performance status criteria: no specifications 6. Other criteria: exclude patients previously treated with >10 cycles of chemotherapy, renal dysfunction
Interventions	1. Active arm: Clodronate Oral 800 mg twice a day for 2 years 7 pts 2. Control arm: Placebo 6 pts All patients received melphalan and prednisone
Outcomes	1. Pain: No pain data within 12 weeks of enrollment Others: a. Mean pain score change at 6 months b. Proportion with radiological progression at 1 year c. Comments on serum calcium, urinary calcium, phosphorus, alkaline phosphatase, and bone histomorphology for subgroup of patients. No withdrawals Adverse effects not reported
Notes	QS = 4