Elomaa 1992.

Methods	Active vs placebo control Definition of pain response: proportion with no pain Analgesic response definition: proportion with no analgesic
Participants	Prostate cancer (failed 1 hormone) Bone metastases required Pain required Co‐intervention: chemotherapy/hormonal therapy Performance status criteria: life expectancy >/=3 months Other criteria: exclude radiotherapy within 2 weeks
Interventions	1. Active arm: Clodronate Oral 3.2 g per day for one month, then 1.6 g per day for 5 months For 6 months 36 pts 2. Control arm: Placebo 39 pts All patients received Estramustine
Outcomes	1. Pain: a. Proportion of patients with no pain 2. Analgesic: Analgesic consumption reduced in 15/17 Clodronate 3/17 placebo Others: a. Serum calcium b. Survival Evaluable data: 12 pts receiving Clodronate and 10 pts from the placebo group died within the first year of the study No adverse effects reported.
Notes	QS = 2