Table 2. HRsa for ESRD incidence in men and women in 25 combined Hb and albuminuria groups.
| Women | Men | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Albuminuria (dipstick) |
Hb group (g/dL) |
No. of subjects | No. of cases | P-value | HR | (95% CI) | Hb group (g/dL) |
No. of subjects | No. of cases | P-value | HR | (95% CI) |
| None | ≥13 | 112,142 | 145 | 1.00 | (Reference) | ≥15 | 126,138 | 223 | 1.00 | (Reference) | ||
| 12–12.9 | 78,635 | 112 | .084 | 1.24 | (0.97–1.59) | 14–14.9 | 89,734 | 197 | .042 | 1.22 | (1.01–1.48) | |
| 11–11.9 | 23,826 | 59 | < .001 | 2.29 | (1.69–3.11) | 13–13.9 | 39,412 | 147 | < .001 | 1.86 | (1.51–2.30) | |
| 10–10.9 | 6,589 | 39 | < .001 | 6.29 | (4.40–8.98) | 12–12.9 | 9,236 | 72 | < .001 | 3.47 | (2.64–4.55) | |
| <10 | 3,981 | 30 | < .001 | 11.16 | (7.46–16.70) | <12 | 2,824 | 60 | < .001 | 10.40 | (7.74–13.97) | |
| Trace | ≥13 | 1,879 | 10 | < .001 | 3.21 | (1.68–6.11) | ≥15 | 2,135 | 17 | < .001 | 3.04 | (1.85–4.99) |
| 12–12.9 | 1,238 | 7 | < .001 | 4.09 | (1.91–8.74) | 14–14.9 | 1,327 | 12 | < .001 | 3.78 | (2.11–6.76) | |
| 11–11.9 | 382 | 7 | < .001 | 12.91 | (6.03–27.62) | 13–13.9 | 607 | 8 | < .001 | 5.05 | (2.49–10.25) | |
| 10–10.9 | 136 | 3 | < .001 | 17.97 | (5.70–56.63) | 12–12.9 | 170 | 10 | < .001 | 17.20 | (9.06–32.64) | |
| <10 | 53 | 4 | < .001 | 139.09 | (50.98–379.53) | <12 | 55 | 4 | < .001 | 23.17 | (8.58–62.57) | |
| 1+ | ≥13 | 1,710 | 16 | < .001 | 4.96 | (2.95–8.34) | ≥15 | 1,914 | 37 | < .001 | 5.54 | (3.90–7.87) |
| 12–12.9 | 985 | 23 | < .001 | 14.17 | (9.08–22.11) | 14–14.9 | 962 | 39 | < .001 | 11.65 | (8.24–16.48) | |
| 11–11.9 | 308 | 8 | < .001 | 17.32 | (8.46–35.45) | 13–13.9 | 478 | 27 | < .001 | 15.86 | (10.57–23.78) | |
| 10–10.9 | 103 | 11 | < .001 | 54.91 | (29.50–102.21) | 12–12.9 | 186 | 17 | < .001 | 23.96 | (14.53–39.52) | |
| <10 | 66 | 6 | < .001 | 120.44 | (52.69–275.30) | <12 | 63 | 8 | < .001 | 24.73 | (12.09–50.56) | |
| 2+ | ≥13 | 577 | 17 | < .001 | 14.58 | (8.77–24.23) | ≥15 | 729 | 26 | < .001 | 9.39 | (6.22–14.16) |
| 12–12.9 | 384 | 16 | < .001 | 20.49 | (12.16–34.53) | 14–14.9 | 367 | 23 | < .001 | 16.45 | (10.61–25.50) | |
| 11–11.9 | 110 | 6 | < .001 | 31.50 | (13.79–71.95) | 13–13.9 | 224 | 28 | < .001 | 31.98 | (21.35–47.90) | |
| 10–10.9 | 44 | 8 | < .001 | 81.58 | (39.78–167.27) | 12–12.9 | 79 | 14 | < .001 | 40.33 | (23.16–70.25) | |
| <10 | 42 | 11 | < .001 | 272.59 | (145.61–510.29) | <12 | 61 | 31 | < .001 | 136.43 | (92.10–202.09) | |
| ≥3+ | ≥13 | 151 | 10 | < .001 | 28.84 | (15.10–55.10) | ≥15 | 191 | 22 | < .001 | 29.48 | (18.93–45.89) |
| 12–12.9 | 97 | 11 | < .001 | 51.39 | (27.46–96.18) | 14–14.9 | 118 | 13 | < .001 | 22.44 | (12.72–39.58) | |
| 11–11.9 | 32 | 5 | < .001 | 146.39 | (59.64–359.34) | 13–13.9 | 63 | 14 | < .001 | 46.88 | (27.00–81.38) | |
| 10–10.9 | 12 | 4 | < .001 | 435.83 | (157.67–1204.72) | 12–12.9 | 29 | 13 | < .001 | 88.17 | (49.61–156.70) | |
| <10 | 15 | 7 | < .001 | 810.56 | (375.01–1751.97) | <12 | 21 | 10 | < .001 | 163.25 | (85.07–313.29) | |
CI, confidence interval; ESRD, end-stage renal disease: Hb, hemoglobin; HR, hazard ratio
a Adjustment for age at baseline, smoking status, alcohol use, physical activity, income status, diabetes, hypertension, a history of heart disease or stroke, a history of cancer, dipstick hematuria, total cholesterol, and body mass index.