Table 5. Comparison to human data.
The total mean values of all parameters measured in each of the three minipig age groups and the corresponding data of humans from the scientific literature. The three different colors identify the differences between the age-group values of the minipigs and the mean values of human data, presented as a minipig/human ratio (MP:H). Ratios lower than 0.85 and higher than 1.15 were defined as substantial anatomical deviations (in red) between the two species where no comparability is present. Parameters with ratios within the range of 0.85 and 1.15 were considered to have a moderate (>0.85 and <1.15 in yellow) or a high (>0.9 and <1.1 in green) comparability.
| Param. | Age (m) | Minipigs ( ± SD) | Humans ( ± SD) | Authors | MP/H-ratio |
|---|---|---|---|---|---|
| MRH | 12 | 73.4 ± 3.4 mm | 53.1 ± 5.3 mm; 56.5 ± 5.1 mm; 57.6 ± 5.8 mm; 59.3 mm | Lopez et al. [57]; Moshiri et al. [58]; Bayome et al. [59]; Ozturk et al. [60]Moshiri et al. [58]Ozturk et al. [60] | 0.771 |
| 17 | 78.1 ± 3.9 mm | 0.725 | |||
| 21 | 81.6 ± 4.0 mm | 0.694 | |||
| MRH | 12 | 74.5 ± 3.7 mm | 53.2 ± 3.6 mm; 64.5 ± 4.2 mm | Franklin et al. [61]; Kim et al. [62] | 0.789 |
| 17 | 77.2 ± 3.6 mm | 0.762 | |||
| 21 | 81.5 ± 5.0 mm | 0.721 | |||
| iMBL | 12 | 105.7 ± 2.7 mm | 72.7 ± 5.3 mm; 79.4 ± 5.6 mm; 79.4 ± 5.6 mm; 88.0 ± 5.0 mm and 93.0 ± 5.0 mm | Steyn and Iscan [63]; Moshiri et al. [58]; Bayome et al. [59]; Weijs and Hillen [64] | 0.787 |
| 17 | 112.5 ± 3.3 mm | 0.740 | |||
| 21 | 120.3 ± 2.9 mm | 0.692 | |||
| MBL | 12 | 144.3 ± 5.2 mm | No comparison possible | ||
| 17 | 152.1 ± 3.2 mm | ||||
| 21 | 160.4 ± 4.1 mm | ||||
| DL | 12 | 14.6 ± 2.4 mm | No comparison possible | ||
| 17 | 14.5 ± 1.5 mm | ||||
| 21 | 15.3 ± 1.7 mm | ||||
| DAL | 12 | 57.2 ± 7.8 mm | 38.4 ± 2.7 mm; 41.5 and 44.7 mm | Al-Zubair et al. [65]; Braun et al. [66] | 0.726 |
| 17 | 61.3 ± 1.6 mm | 0.678 | |||
| 21 | 63.2 ± 5.6 mm | 0.657 | |||
| IB | 12 | 33.4 ± 1.4 mm | No comparison possible | ||
| 17 | 35.5 ± 1.3 mm | ||||
| 21 | 37.6 ± 1.2 mm | ||||
| LIB | 12 | 28.3 ± 1.2 mm | 24.4 ± 1.4 mm; 25.4 ± 1.8 mm; 25.3 ± 0.9 mm and 26.4 ± 2.9 mm | Bishara et al. [67]; Singh et al. [68]; Tamewar et al. [69] | 0.897 |
| 17 | 29.2 ± 1.8 mm | 0.869 | |||
| 21 | 30.4 ± 2.1 mm | 0.802 | |||
| MIB | 12 | 20.6 ± 1.6 mm | 11.5 mm; 15.2 mm | Ozturk et al. [60]; Tebo and Telford [70] | 0.648 |
| 17 | 22.9 ± 2.1 mm | 0.583 | |||
| 21 | 23.9 ± 2.1 mm | 0.559 | |||
| MAC | 12 | 13.4 ± 1.8 mm | 11.4 mm; 11.8 ± 3.0 mm | Ozturk et al. [60]; Lorenzo et al. [71] | 0.866 |
| 17 | 10.6 ± 1.5 mm | 0.906 | |||
| 21 | 11.4 ± 1.6 mm | 1.017 | |||
| MGO | 12 | 81.6 ± 2.6 mm | 74.6 mm | Tebo and Telford [70] | 0.914 |
| 17 | 85.7 ± 3.2 mm | 0.870 | |||
| 21 | 90.9 ± 3.7 mm | 0.820 | |||
| IFB | 12 | 51.6 ± 2.9 mm | 44.6 ± 2.5 mm; 43.2 ± 2.8 mm; 47.2 ± 2.8 mm and 49.9 ± 3.0 mm | Lopez et al. [57]; Kumar et al. [72]; Dong et al. [73] | 0.853 |
| 17 | 55.8 ± 2.9 mm | 0.806 | |||
| 21 | 57.9 ± 2.8 mm | 0.781 | |||
| GA | 12 | 97.5 ± 4.4° | 115.5 ± 4.0°; 118.6 ± 5.2°; 123.9 ± 7.3°; 125.7 ± 5.6° | Bayome et al. [59]; Weijs and Hillen [64]; Lopez et al. [57]; Dong et al. [73] | 1.194 |
| 17 | 99.4 ± 3.8° | 1.178 | |||
| 21 | 97.3 ± 4.4° | 1.195 | |||
| MRL | 12 | 42.3 ± 2.1 mm | 32.7 ± 2.8 mm; 37.8 ± 2.9 mm and 39.8 ± 3.7 mm | Kim et al. [62]; Giles [74] | 0.869 |
| 17 | 42.3 ± 1.5 mm | 0.869 | |||
| 21 | 44.5 ± 1.1 mm | 0.826 | |||
| SRL | 12 | 25.4 ± 2.2 mm | 31.3 ± 2.9 mm; 33.5 ± 3.6 mm | Lopez et al. [57]; Kim et al. [75] | 1.216 |
| 17 | 27.4 ± 1.6 mm | 1.154 | |||
| 21 | 27.4 ± 1.7 mm | 1.154 | |||
| CPV | 12 | 193.4 ± 82.3 mm³ | 250.0 ± 9.0 mm³ | Gomes et al. [76] | 1.226 |
| 17 | 108.2 ± 56.4 mm³ | 1.567 | |||
| 21 | 187.8 ± 95.0 mm³ | 1.249 | |||
| MCV | 12 | 1.9 ± 0.5 ml | 2.3 ml and 2.4 ml; 2.7 ± 0.4 ml | Safi et al. [77]; Saccucci et al. [78] | 1.230 |
| 17 | 2.7 ± 0.4 ml | 0.914 | |||
| 21 | 2.9 ± 0.7 ml | 0.851 | |||
| AMH | 12 | 45.9 ± 4.5 mm | 24.6 mm; 28.5 ± 3.0 mm; 29.6 ± 3.5 mm | Ozturk et al. [60]; Giles [74]; Kumar et al. [72] | 0.600 |
| 17 | 46.0 ± 2.8 mm | 0.599 | |||
| 21 | 48.0 ± 3.4 mm | 0.574 | |||
| ICOB | 12 | 68.0 ± 2.4 mm | 90.8 ± 5.7 mm; 92.0 ± 5.7 mm | Lopez et al. [57]; Kumar et al. [72] | 1.251 |
| 17 | 71.4 ± 1.8 mm | 1.219 | |||
| 21 | 73.5 ± 1.6 mm | 1.244 | |||
| SNB | 12 | 75.3 ± 4.3 mm | No available data | ||
| 17 | 77.4 ± 3.7 mm | ||||
| 21 | 80.1 ± 2.9 mm | ||||
| ICB | 12 | 88.1 ± 4.1 mm | 111.2 ± 6.2 mm and 117.0 ± 5.3 mm; 110.5 ± 6.2 mm and 116.4 ± 7.0 mm | Steyn and Iscan [63]; Lopez et al. [57] | 1.226 |
| 17 | 88.9 ± 2.9 mm | 1.219 | |||
| 21 | 91.6 ± 3.5 mm | 1.195 | |||
| IGB | 12 | 97.0 ± 7.7 mm | 85.9 ± 5.0 mm; 91.5 ± 5.0 mm; 91.8 ± 5.9 mm; 93.7 ± 6.8 mm | Ozturk et al. [60]; Steyn and Iscan [63]; Lopez et al. [57]; Carvalho et al. [79] | 0.935 |
| 17 | 106.6 ± 3.6 mm | 0.851 | |||
| 21 | 111.8 ± 4.8 mm | 0.811 | |||