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. 2019 Apr 25;14(4):e0215996. doi: 10.1371/journal.pone.0215996

Table 2. Parameters associated with recommended candidemia treatment and results, n = 283.

Variable With IDC Without IDC OR (95% CI) P value
(n = 126, 44.5%) (n = 157, 55.1%)
Definitive antifungal therapy Appropriate antifungal choice (n = 276) a 120/124 (96.8) 125/152 (82.2) 6.48 (2.20–19.07) <0.001
Liposomal amphotericin b 4 (3.2) 3 (2.0) 1.66 (0.36–7.54) 0.70
Fluconazole 51 (41.1) 19 (12.5) 4.89 (2.69–8.90) <0.001
Echinocandin 9 (7.3) 12 (7.9) 0.91 (0.37–2.24) 0.84
Voriconazole 0 (0.0) 3 (2.0) 0.26
Appropriate planned duration of antifungal therapy (n = 280)b 105/125 (84.0) 89/155 (57.4) 3.89 (2.19–6.92) <0.001
Median duration of antifungal therapyb 19 (15–31) 14 (6–20) <0.001
Intervention Transthoracic echocardiogram 22 (17.5) 1 (0.6) 33.00 (4.38–248.59) <0.001
Adequate source control 106 (84.1) 130 (82.8) 1.10 (0.59–2.07) 0.77
CVC removal 86 (68.3) 120 (76.4) 0.66 (0.39–1.12) 0.12
Early CVC removal (≤ 48 hours) 65 (51.6) 102 (65.0) 0.58 (0.36–0.93) 0.023
Peripheral-line removal 17 (13.5) 8 (5.1) 2.91 (1.21–6.97) 0.013
Intra-abdominal drainage 3 (2.4) 2 (1.3) 1.89 (0.31–11.49) 0.66
Consultation to Ophthalmologist 98 (77.8) 54 (34.4) 6.68 (3.92–11.38) <0.001
Performed the ecocardiography 22 (17.5) 1 (0.6) 33.00 (4.38–248.59) <0.001

Unless otherwise stated, data are presented as n (%)

IDC, infectious disease consultation; OR, odds ratio; CI, confidence interval; IQR, interquartile range; CVC, central venous catheter

aAppropriate antifungal choice was unspecified for 7patients due to unclassified Candida species.

bDuration of therapy was unspecified for 3 patients.