Table 2. Parameters associated with recommended candidemia treatment and results, n = 283.
Variable | With IDC | Without IDC | OR (95% CI) | P value | ||||
---|---|---|---|---|---|---|---|---|
(n = 126, 44.5%) | (n = 157, 55.1%) | |||||||
Definitive antifungal therapy | Appropriate antifungal choice (n = 276) a | 120/124 | (96.8) | 125/152 | (82.2) | 6.48 | (2.20–19.07) | <0.001 |
Liposomal amphotericin b | 4 | (3.2) | 3 | (2.0) | 1.66 | (0.36–7.54) | 0.70 | |
Fluconazole | 51 | (41.1) | 19 | (12.5) | 4.89 | (2.69–8.90) | <0.001 | |
Echinocandin | 9 | (7.3) | 12 | (7.9) | 0.91 | (0.37–2.24) | 0.84 | |
Voriconazole | 0 | (0.0) | 3 | (2.0) | 0.26 | |||
Appropriate planned duration of antifungal therapy (n = 280)b | 105/125 | (84.0) | 89/155 | (57.4) | 3.89 | (2.19–6.92) | <0.001 | |
Median duration of antifungal therapyb | 19 | (15–31) | 14 | (6–20) | <0.001 | |||
Intervention | Transthoracic echocardiogram | 22 | (17.5) | 1 | (0.6) | 33.00 | (4.38–248.59) | <0.001 |
Adequate source control | 106 | (84.1) | 130 | (82.8) | 1.10 | (0.59–2.07) | 0.77 | |
CVC removal | 86 | (68.3) | 120 | (76.4) | 0.66 | (0.39–1.12) | 0.12 | |
Early CVC removal (≤ 48 hours) | 65 | (51.6) | 102 | (65.0) | 0.58 | (0.36–0.93) | 0.023 | |
Peripheral-line removal | 17 | (13.5) | 8 | (5.1) | 2.91 | (1.21–6.97) | 0.013 | |
Intra-abdominal drainage | 3 | (2.4) | 2 | (1.3) | 1.89 | (0.31–11.49) | 0.66 | |
Consultation to Ophthalmologist | 98 | (77.8) | 54 | (34.4) | 6.68 | (3.92–11.38) | <0.001 | |
Performed the ecocardiography | 22 | (17.5) | 1 | (0.6) | 33.00 | (4.38–248.59) | <0.001 |
Unless otherwise stated, data are presented as n (%)
IDC, infectious disease consultation; OR, odds ratio; CI, confidence interval; IQR, interquartile range; CVC, central venous catheter
aAppropriate antifungal choice was unspecified for 7patients due to unclassified Candida species.
bDuration of therapy was unspecified for 3 patients.