Khorasani 2009.

Methods	Country where data collected: Iran RCT with intra‐individual design Unit of randomisation: burn Unit of analysis: burn Duration: 24 days
Participants	Inclusion criteria: 2 comparable second‐degree ("same site") burns e.g. on hands or feet with similar areas Exclusion criteria: electrical or chemical burns, diabetes, pregnancy, immunodeficiency, kidney disease Participants: 30 participants with 2 comparable burns Mean age (years): 33 (± 11) Male participants: 25/30 Burn type: NR Burn degree: 2nd degree Burn size (%TBSA): 19.8 ± 7.9 Burn location: 26 burns on right and left hand, 2 on right and left foot, 2 on right or left hand
Interventions	Intervention arm 1: 0.5% A vera cream produced from powder applied twice daily. 30 burns Intervention arm 2: SSD (concentration not explicitly stated) applied twice daily. 30 burns Cointerventions: wound cleaning with water and saline; dressings; fluid resuscitation; "other treatment protocols"; oral nutrition; occasional amino acid infusions; blood products
Outcomes	Primary outcome: wound healing Primary outcome: infection
Notes	Funding: Mazandaran University, Iran This was a "split‐body" or "intra‐individual" design where a person with two wounds had one wound randomised to each treatment. It was not clear whether the analysis took account of this.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Quote: “Each patient had one burn treated with topical SSD and one treated with aloe cream, randomly.” Comment: no further details on randomisation method
Allocation concealment (selection bias)	Unclear risk	Quote: “Each patient had one burn treated with topical SSD and one treated with aloe cream, randomly.” Comment: no further details on allocation
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Quote: ”At the time of each dressing, the wound was observed clinically for signs of infection, size, and rate and nature of epithelialization by an expert surgeon. In this study, the “B” part of the body was treated with SSD and the “A” part was treated with aloe cream. Patients and nursing staff were blinded to the procedure.” Comment: no mention of blinding of the surgeon/assessors
Incomplete outcome data (attrition bias) All outcomes	Low risk	Quote: "Finally, 30 patients were enrolled in this study.” Comment: 30 participants included in outcome reporting
Selective reporting (reporting bias)	Unclear risk	“At the time of each dressing, the wound was observed clinically for signs of infection, size, and rate and nature of epithelialization by an expert surgeon.” Comment: results of visual infection checks not reported (though the study does report on microbial swab contamination)
Other bias	Unclear risk	Comment: unclear whether analysis took into account the intra‐individual design