Liao 2006.
| Methods | Country where data collected: China Parallel‐group RCT (intra‐individual) Unit of randomisation: burn Unit of analysis: burn Duration: NR (until healing) |
|
| Participants | Inclusion criteria: second‐degree burns (superficial or deep) within 72 h of injury; TBSA ≤ 60% Exclusion criteria: general infection, pregnancy, patients with serious heart, kidney or liver disease (AST > 1.5; ALT > 1.5); "mental disease" Participants: 120 hospital patients Mean age (years): NR Male participants: 99/120 Burn type: NR Burn degree: second‐degree; superficial/deep 80/40 Burn size (%TBSA): NR about 100 cm2 Burn location: NR |
|
| Interventions | Intervention arm 1: 0.1% silver nitrate changed every other day Intervention arm 2: 1% SSD changed every other day Cointerventions: wound cleansing with isotonic saline; treatment duration 14 days for superficial wounds, 28 days for deep wounds |
|
| Outcomes | Primary outcome: wound healing Secondary outcome: adverse events |
|
| Notes | Article in Chinese, extracted and assessed for risk of bias by one review author, discussed with a second review author Funding NR This was a "split‐body" or "intra‐individual" design where a person with two wounds had one wound randomised to each treatment. It was not clear whether the analysis took account of this. |
|
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Unclear risk | Comment: a random component in the sequence generation process was not reported in detail |
| Allocation concealment (selection bias) | Unclear risk | Comment: it did not state how randomisation sequence was allocated |
| Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Comment: not mentioned |
| Incomplete outcome data (attrition bias) All outcomes | Low risk | Comment: results section and tables show that all participant data were included in analysis |
| Selective reporting (reporting bias) | Low risk | Comment: protocol not obtained, based on paper only |
| Other bias | Unclear risk | The whole process of conducting this RCT was not clear including whether the analysis took account of the intra‐individual design |