Piccolo‐Daher 1990.

Methods	Country where data collected: Brazil Parallel‐group RCT Unit of randomisation: participant Unit of analysis: burn Duration: NR
Participants	Inclusion criteria: second‐degree burns 1%‐20% TBSA Exclusion criteria: NR Participants: 125 Mean age (years): NR Male participants: NR Burn type: NR Burn degree: second‐degree Burn size (%TBSA): mean 4% Burn location: NR
Interventions	Intervention group 1: merbromin 2% N = 25 Intervention group 2: sodium salicylate 2% N = 25 Intervention group: zinc sulfadiazine 2% N = 25 Intervention group 4: sodium salicylate 2% + zinc sulfadiazine 2% N = 25 Intervention group 5: collagenase 0.6 μg/g + chloramphenicol 1% N = 25 Cointerventions: surgical debridement under general anaesthesia; occlusive dressings after topical application
Outcomes	Primary outcome: wound healing
Notes	Funding NR. Study reported in Portuguese; data extraction and risk of bias provided by two translators. Although the unit of analysis is stated to be "burns" it appears that there was only one burn per participant.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Method of randomisation not reported
Allocation concealment (selection bias)	Unclear risk	Allocation concealment was not reported
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Time to wound healing was analysed by an observer who was blinded to the participant's treatment group
Incomplete outcome data (attrition bias) All outcomes	Low risk	No losses to follow‐up
Selective reporting (reporting bias)	Low risk	all proposed outcomes were reported
Other bias	Unclear risk	Unclear whether the groups had similar baseline characteristics