Thamlikitkul 1991.
| Methods | Country where data collected: Singapore Parallel‐group RCT Unit of randomisation: participant Unit of analysis: participant Duration: 26 days |
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| Participants | Inclusion criteria: thermal 1st‐ or 2nd‐degree burns, < 30% TBSA, within 24 h of admission with no prior antibiotics or topical treatment for burn Exclusion criteria: diabetes mellitus and terminal patients Participants: 38 patients at 2 community hospitals Mean age (years): 18 vs 25.2 Male participants: 11 vs 11 Burn type: thermal 18 vs 17; electrical 2 vs 1 Burn degree: 1st 9 vs 5; 2nd 11 vs 13 Burn size (%TBSA): 8 vs 11.1 Burn location: NR |
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| Interventions | Intervention arm 1: Aloe vera Linn. mucilage dressings changed twice daily Intervention arm 2: SSD dressings changed twice daily Cointerventions: intravenous fluid 6 vs 6; antibiotics 12 vs 12, analgesia 13 vs 13, tetanus 2 vs 1, sedatives 2 vs 2, other 2 vs 0 |
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| Outcomes | Primary outcome: wound healing secondary outcome: adverse events |
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| Notes | No funding reported | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Unclear risk | Quote: "Eligible patients were designated to receive Aloe vera Linn., mucilage or silver sulfadiazine for topical treatment of their burns by stratified randomization selection based on two prognostic factors...." Comment: unclear how randomisation sequence was derived |
| Allocation concealment (selection bias) | Unclear risk | Quote: "Eligible patients were designated to receive Aloe vera Linn., mucilage or silver sulfadiazine for topical treatment of their burns by stratified randomization selection based on two prognostic factors...." Comment: unclear whether treatment allocations were adequately concealed |
| Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Quote: "Each patient was assessed daily for healing, side effects and satisfaction with the treatment" Comment: no information on whether assessment was conducted in a blinded fashion |
| Incomplete outcome data (attrition bias) All outcomes | Low risk | Comment: no specific quote but all randomised participants included in analysis |
| Selective reporting (reporting bias) | Unclear risk | Comment: no specific quote |
| Other bias | Unclear risk | Comment: no evidence of other sources of bias but reporting insufficient to be certain |