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. 2017 Jul 12;2017(7):CD011821. doi: 10.1002/14651858.CD011821.pub2

Thomas 1995.

Methods Country where data collected: UK
Parallel‐group RCT
Unit of randomisation: participant
Unit of analysis: burn
Duration: NR
Participants Inclusion criteria: < 5% TBSA, presented up to 24 h post burn
Exclusion criteria: burns to face, neck, axilla; chemical and electrical burns
Participants: 50 participants with 54 burns
Mean age (years): NR; children 10/18 vs 7/16 vs 7/16
Male participants: NR; ratios 2:1 vs 1:1.3 vs 1:1.3 no significant difference between groups
Burn type: scalds 95% vs 56% vs 88%; no significant difference between groups
Burn degree: NR (minor)
Burn size (%TBSA): 0.84 vs 0.94 vs 0.79; no significant difference between groups
Burn location: NR
Interventions Intervention arm 1: chlorhexidine tulle‐gras. N = 18
Intervention arm 2: hydrocolloid (granuflex). N = 16
Intervention arm 3: hydrocolloid + SSD. N = 16
Cointerventions: NR
Outcomes Primary outcome: wound healing
Secondary outcome: pain
Notes Funding: Convatec/Squibb supplied granuflex
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Quote: "Patients were randomly allocated to one of three treatment groups after obtaining informed consent"
Comment: no information on how the randomisation sequence was generated
Allocation concealment (selection bias) Unclear risk Quote: "Patients were randomly allocated to one of three treatment groups after obtaining informed consent".
Comment: no information on whether allocation concealment was adequate
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk Quote: "During dressing changes the healing progress of the wound was noted..."
Comment: no information on whether observers were blinded; balance of probabilities would be not
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk Comment: no specific quote but unclear whether all randomised participants were included in analysis
Selective reporting (reporting bias) Low risk Comment: no specific quote but outcomes mentioned in early part of text are reported in findings
Other bias High risk Comment: unit of analysis issues as randomisation was at the participant level whilst analysis was at the level of burn wounds (some participants had multiple burns)