Thomas 1995.
| Methods | Country where data collected: UK Parallel‐group RCT Unit of randomisation: participant Unit of analysis: burn Duration: NR |
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| Participants | Inclusion criteria: < 5% TBSA, presented up to 24 h post burn Exclusion criteria: burns to face, neck, axilla; chemical and electrical burns Participants: 50 participants with 54 burns Mean age (years): NR; children 10/18 vs 7/16 vs 7/16 Male participants: NR; ratios 2:1 vs 1:1.3 vs 1:1.3 no significant difference between groups Burn type: scalds 95% vs 56% vs 88%; no significant difference between groups Burn degree: NR (minor) Burn size (%TBSA): 0.84 vs 0.94 vs 0.79; no significant difference between groups Burn location: NR |
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| Interventions | Intervention arm 1: chlorhexidine tulle‐gras. N = 18 Intervention arm 2: hydrocolloid (granuflex). N = 16 Intervention arm 3: hydrocolloid + SSD. N = 16 Cointerventions: NR |
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| Outcomes | Primary outcome: wound healing Secondary outcome: pain |
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| Notes | Funding: Convatec/Squibb supplied granuflex | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Unclear risk | Quote: "Patients were randomly allocated to one of three treatment groups after obtaining informed consent" Comment: no information on how the randomisation sequence was generated |
| Allocation concealment (selection bias) | Unclear risk | Quote: "Patients were randomly allocated to one of three treatment groups after obtaining informed consent". Comment: no information on whether allocation concealment was adequate |
| Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Quote: "During dressing changes the healing progress of the wound was noted..." Comment: no information on whether observers were blinded; balance of probabilities would be not |
| Incomplete outcome data (attrition bias) All outcomes | Unclear risk | Comment: no specific quote but unclear whether all randomised participants were included in analysis |
| Selective reporting (reporting bias) | Low risk | Comment: no specific quote but outcomes mentioned in early part of text are reported in findings |
| Other bias | High risk | Comment: unit of analysis issues as randomisation was at the participant level whilst analysis was at the level of burn wounds (some participants had multiple burns) |