Alipour 2017.
Methods | Randomised controlled trial |
Participants | 32 neonates born at 34 weeks or later with PPHN (cyanosis that continued 30 minutes after ventilation with 100% supplemental oxygen via hood) Group 1: n = 16 No participant demographics were reported Group 2: n = 16 No participant demographics were reported |
Interventions | Tadalafil orally; 1 mg/kg/d Sildenafil orally; 1 mg/kg/dose 3 times daily |
Outcomes | Tricuspid regurgitation (TR) severity assessed by echocardiography at baseline and after 6 months Mean pulmonary arterial pressure (MPAP) recorded via echocardiography based on gradient of pulmonary insufficiency or gradient TR on Doppler echocardiography Right ventricular end‐diastolic diameter (RVEDD) assessed by echocardiography at baseline and after 6 months Main pulmonary artery (MPA) diameter assessed by echocardiography at baseline and 6 months after treatment |
Notes | Funding support, potential conflicts, and trial registration were not reported. This study was classified as awaiting classification, as the review authors required clarification of the time period of measurement. It is reported that echocardiography took place 6 months after treatment, which we believe could have taken hours. We have contacted the corresponding author multiple times |