. 2001 Oct 18;2(6):298–306. doi: 10.1186/cvm-2-6-298

Table 1.

Patient characteristics at baseline and at the end of the Syst-Eur 1 trial

	Baseline Syst-Eur 1		Baseline Syst-Eur 2

Characteristic	Placebo	Active	Placebo^†		Active^†
Number	1691	1825	1691		1825
Female sex	1121 (66.3%)	1219 (66.8%)	1121 (66.3%)		1219 (66.8%)
Age (years)	69.0 ± 6.0	69.0 ± 5.8	71.1 ± 6.4⁺⁺		71.2 ± 6.3⁺⁺
Sitting systolic blood pressure (mmHg)	173.4 ± 9.5	173.3 ± 9.4	160.4 ± 16.2⁺⁺	^***	151.0 ± 14.6⁺⁺
Sitting diastolic blood pressure (mmHg)	85.6 ± 5.7	85.7 ± 5.7	83.4 ± 7.7⁺⁺	^***	79.6 ± 7.8⁺⁺
Sitting heart rate (beats per minute)	72.8 ± 8.0	72.8 ± 7.9	72.5 ± 9.1	^*	73.1 ± 8.9
Standing systolic blood pressure (mmHg)	168.3 ± 11.5	167.9 ± 11.9	157.6 ± 16.6⁺⁺	^***	148.2 ± 15.5⁺⁺
Standing diastolic blood pressure (mmHg)	87.6 ± 7.6	87.6 ± 7.6	85.1 ± 9.2⁺⁺	^***	81.6 ± 8.9⁺⁺
Body-mass index (kg/m²)	27.3 ± 4.0	27.3 ± 4.2	27.0 ± 4.0⁺⁺		27.1 ± 4.2⁺⁺
Total cholesterol (mmol/l)	6.0 ± 1.2	6.0 ± 1.2	5.9 ± 1.1⁺⁺		5.8 ± 1.1⁺⁺
High-density-lipoprotein cholesterol (mmol/l)	1.40 ± 0.46	1.42 ± 0.48	1.36 ± 0.40⁺	^*	1.40 ± 0.47
History of stroke	18 (1.1%)	20 (1.1%)	39 (2.3%)⁺⁺		34 (1.9%)⁺⁺
History of myocardial infarction	61 (3.6%)	62 (3.4%)	73 (4.3%)⁺⁺	^**	71 (3.9%)⁺⁺
Diabetes mellitus	170 (10.1%)	189 (10.4%)	205 (12.1%)⁺⁺		235 (12.9%)⁺⁺
Current smokers	106 (6.3%)	121 (6.6%)	71 (4.2%)⁺⁺		86 (4.7%)⁺⁺
Abstaining from alcohol	1227 (72.6%)	1311 (71.9%)	1324 (78.3%)⁺⁺		1388 (76.1%)⁺⁺
<1 unit alcohol per day	282 (16.7%)	337 (18.4%)	225 (13.3%)⁺⁺		261 (14.3%)⁺⁺
≥ 1 unit alcohol per day	181 (10.7%)	176 (9.7%)	142 (8.4%)⁺⁺		175 (9.6%)

Values are given as mean ± SD or number of patients (%). ^† Indicates patients formerly randomised to placebo and active treatment. Significance of between-group differences: ^*P < 0.05; ^**P < 0.01; ^***P < 0.001. Significance of within-group changes: ⁺P < 0.01; ⁺⁺P < 0.001.