Guerrero 2008

Methods	RCT.  Details not given in abstract of trial. 3 treatment arms. 4 centres. Follow‐up 6 months and 1 year
Participants	201 women randomised (mean age 52 years) to Pelvicol‐50, TVT‐72, autologous sling‐79. 85% were available for follow‐up at 1 year Inclusion criteria: women requiring primary surgical treatment for urodynamic SUI
Interventions	A (79) autologous sling B (50) Pelvicol C (72) TVT
Outcomes	Success and improvement rates were described Other outcome measures included: operative details, complications, dry/ improved rates, QoL assessment, catheterisation and re‐operation rates Median theatre time (min): A: 50, B: 35, C: 30 Median length post‐op stay (days): A: 4, B: 4, C: 2 Incontinent at 6 months: A: 41/79, B: 28/50, C: 35/72 Incontinent at 12 months : A: 41/79, B: 39/50, C: 32/72 Not improved at 6 months: A: 4/79, B: 13/50, C: 6/72 Not improved at 12 months: A: 8/79, B: 19/50, C: 5/72 Re‐operation rate: A: 0%, B: 0%, C: 0% Self‐catherterisation at 12 months: A: 1/79, B: 0/50, C: 0/72
Notes	High re‐operation rates (1 in 5) in Pelvicol group so arm closed.  Study closed at 6 years before target number reached.  Interim analysis after the first 50 participants in each group No mention of how success rate was assessed in the abstract, on contacting a listed author, we were informed that the figures were patient‐reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Insufficient information to make judgement
Allocation concealment (selection bias)	Unclear risk	Insufficient information to make judgement
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Insufficient information to make judgement
Incomplete outcome data (attrition bias) All outcomes	Low risk	No missing outcome data at 12 months. Study closed after 6 years due to failure to recruit target numbers and high reoperation rate