Comparison 1. Low molecular weight heparin versus no prophylaxis or placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Deep venous thrombosis: regardless of type of plaster, whether operated or not	7	1676	Odds Ratio (M‐H, Fixed, 95% CI)	0.45 [0.33, 0.61]
2 Deep venous thrombosis: in below‐knee cast, whether operated or not	6	1080	Odds Ratio (M‐H, Fixed, 95% CI)	0.49 [0.34, 0.72]
3 Deep venous thrombosis: conservative treatment (i.e. non‐operated patients)	5	974	Odds Ratio (M‐H, Fixed, 95% CI)	0.31 [0.18, 0.53]
4 Deep venous thrombosis: operated patients	4	699	Odds Ratio (M‐H, Fixed, 95% CI)	0.54 [0.37, 0.80]
5 Deep venous thrombosis: fractures	6	1003	Odds Ratio (M‐H, Fixed, 95% CI)	0.48 [0.33, 0.70]
6 Deep venous thrombosis: soft‐tissue injuries	5	658	Odds Ratio (M‐H, Fixed, 95% CI)	0.39 [0.22, 0.68]
7 Deep venous thrombosis: distal segment	5	1208	Odds Ratio (M‐H, Fixed, 95% CI)	0.61 [0.42, 0.89]
8 Deep venous thrombosis: proximal segment	5	1217	Odds Ratio (M‐H, Fixed, 95% CI)	0.41 [0.19, 0.91]
9 Pulmonary embolism	5	2517	Odds Ratio (M‐H, Fixed, 95% CI)	0.50 [0.17, 1.47]
10 Symptomatic venous thromboembolism	6	2924	Odds Ratio (M‐H, Fixed, 95% CI)	0.40 [0.21, 0.76]
11 Mortality due to pulmonary embolism	8	3111	Odds Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
12 Mortality due to other causes	8	3111	Odds Ratio (M‐H, Fixed, 95% CI)	0.33 [0.01, 8.15]
13 Adverse outcomes	8	3178	Odds Ratio (M‐H, Random, 95% CI)	2.01 [0.83, 4.86]