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. 2012 Nov 14;2012(11):CD007407. doi: 10.1002/14651858.CD007407.pub3

Keefe 1990.

Methods RCT. 3 arms; assessed pre‐treatment, post‐treatment, 6 months
Participants End of treatment n = 94
Start of treatment n = 99
Sex: 71 F, 28 M
Mean age = 64.0 (SD 11.5)
Source = rheumatology clinic
Diagnosis = osteoarthritis of the knee
Mean years of pain = 12.0
Interventions "coping skills training"
"arthritis education"
"standard care"
Outcomes Primary pain outcome: AIMS pain
Primary disability outcome: AIMS physical disability
Primary mood outcome: AIMS psychological disability
Catastrophising outcome: none
Arthritis Impact Measurement Scale (AIMS): pain 
Arthritis Impact Measurement Scale (AIMS): psychological disability
Arthritis Impact Measurement Scale (AIMS): physical disability
Pain behaviour (Keefe & Block) observation                       
Coping Strategy Questionnaire                          
Medication use
Notes CBT versus active, post‐treatment and follow‐up: analyses 1.1, 1.2, 1.3, 2.1, 2.2, 2.3
CBT versus TAU, post‐treatment and follow‐up: analyses 3.1, 3.2, 3.3, 4.1, 4.2, 4.3
Yates quality scale: total quality = 26/35, design quality = 18/26, treatment quality = 8/9
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk “randomly assigned (using a random number table)”
Allocation concealment (selection bias) High risk Not reported (but equal credibility of treatments rated by participants)
Incomplete outcome data (attrition bias) 
 All outcomes Low risk Fully reported
Selective reporting (reporting bias) Low risk Fully reported
Blinding of outcome assessment (detection bias) 
 All outcomes High risk Not reported