Walsoe 1990.

Methods	Design: double‐blind RCT
Participants	Number of participants randomised: 20 Sex: not stated for toenail subgroup (both sexes included) Mean age: not stated Number included in analysis: 20 Number completing treatment: 20 Inclusion criteria Type/location/characteristics of infection: toenail or fingernail onychomycosis caused by T rubrum or T mentagrophytes Duration of infection: not stated Exclusion criteria: antimycotic therapy within 1 month of start of study, pregnancy or serious concurrent disease Washout period: not explicitly stated, by participants with antimycotic therapy within 1 month of start of study were excluded Setting: not stated, study authors are all from Copenhagen Comorbidities: not stated
Interventions	100 mg itraconazole daily for 6 months 500 mg griseofulvin daily for 6 months
Outcomes	Duration of follow‐up: 12 months Outcomes measured: cure (defined as clinical and mycological cure), marked improvement (defined as positive microscopy and negative culture), and improvement (50% clinical improvement compared to baseline and positive mycology) Safety and tolerability: side effects reported
Source of funding	No information available
Conflict of interest	No conflict of interest identified
Notes	—
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Quote: "double‐blind study ... randomised basis" Comment: method not stated
Allocation concealment (selection bias)	Unclear risk	Quote: "double‐blind study ... randomised basis" Comment: method not stated
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Quote: "[f]or each patient, 12 boxes were prepared, each containing blister packs" Comment: blister packs were used, but it was not clear whether any visual differences remained between treatments
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Quote: "double‐blind study ... randomised basis" Comment: method not stated
Incomplete outcome data (attrition bias) All outcomes	Low risk	All participants included in analysis
Selective reporting (reporting bias)	Low risk	All results presented as set out in the Methods. All prespecified outcomes appear to be reported.
Other bias	Low risk	No other risks of bias identified